Fresh analysis indicates that individuals who stop using new weight-loss injections like Mounjaro or Wegovy can put back on reduced body mass at a significantly accelerated pace than those who end conventional diet and exercise programs.
Published data in a major medical journal demonstrates that while obese individuals can lose about a fifth of their body weight while undergoing treatment, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"Users using these drugs must be informed of the danger of rapid rebound weight gain when the treatment concludes," stated researcher Dr. Susan Jebb.
Such speed of recovery implies a return to starting weight within about 18 months.
Analyzing Treatments
The analysis, which reviewed 37 of studies involving over 9,000 of patients, contrasted the effects of GLP-1 agonists with older methods.
Researchers emphasize that people who shed pounds through dieting generally experience a less rapid creep back—around 100 grams monthly—once they finish.
The Reason for the Quick Rebound
Experts suggest the way of the injections accounts for the amplified weight return.
The injections copy a body's own chemical called glucagon-like peptide-1, which helps regulate hunger.
"Long-term administration of GLP-1 levels several times higher than normal might result in the system to produce less of its endogenous hormone, and could reduce sensitivity to its actions," said Dr. Adam Collins, a dietetics specialist.
"Stopping of this medication leads to hunger is no longer kept in check, making binge eating much more probable."
A Chronic Condition?
The NHS recommend the injections for individuals with weight-linked health risks, accompanied by prescribed lifestyle changes.
Many experts argue that, considering the high risk of relapse, the treatment might need to be long-term.
This view is echoed by drug manufacturers, who note that the results "highlight the persistent character of excess weight," similar to managing conditions like high blood pressure.
Patient Testimonies
Individuals who have discontinued the jabs report a powerful return of cravings.
"I experienced a switch that goes on and I was suddenly extremely hungry," recalled an individual.
The struggle is exacerbated if individuals have not established sustainable lifestyle or habit changes during therapy.
Growing Interest
Recent estimates suggest that millions of people in the UK have used weight-loss jabs in the past year, with desire being substantial.
- Use is more common among females than males.
- The middle-aged age group shows the highest level of interest.
- Many obtain the medications through private healthcare rather than public health services.
Ultimately, experts caution that while the jabs are potent tools for shedding pounds, they are not a permanent solution and maintained weight loss relies on combined lifestyle management.
